Article
Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics.
Insect biochemistry and molecular biology - 1 Nov 2015
Jiang Dingxin, Du Yuzhe, Nomura Yoshiko, Wang Xingliang, Wu Yidong, Zhorov Boris S, Dong Ke
Abstract excerpt
Indoxacarb and metaflumizone are two sodium channel blocker insecticides (SCBIs). They preferably bind to and trap sodium channels in the slow-inactivated non-conducting state, a mode of action similar to that of local anesthetics (LAs). Recently, two sodium channel mutations, F1845Y (F(4i15)Y) and V1848I (V(4i18)I), in the transmembrane segment 6 of domain IV (IVS6), were identified to be associated with...
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