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Article

Abnormal γ-aminobutyric acid neurotransmission in a Kcnq2 model of early onset epilepsy.

Epilepsia - 1 Aug 2017

Uchida Taku, Lossin Christoph, Ihara Yukiko, Deshimaru Masanobu, Yanagawa Yuchio, Koyama Susumu, Hirose Shinichi

Abstract excerpt

OBJECTIVE: Mutations of the KCNQ2 gene, which encodes the Kv 7.2 subunit of voltage-gated M-type potassium channels, have been associated with epilepsy in the neonatal period. This developmental stage is unique in that the neurotransmitter gamma aminobutyric acid (GABA), which is inhibitory in adults, triggers excitatory action due to a reversed chloride gradient. METHODS: To examine whether KCNQ2-related...

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PMID: 28575529
DOI: 10.1111/epi.13807

Genes

KCNQ2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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