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Article

Neuropathology findings in KCNQ2 neonatal epileptic encephalopathy.

Seizure - 1 Jul 2022

Legros Ludovic, Adle-Biassette Homa, Dozières-Puyravel Blandine, Khung Suonavy, Elmaleh-Bergès Monique, Lesca Gaëtan, Delanoë Catherine, Biran Valérie, Auvin Stéphane

Abstract excerpt

PURPOSE: KCNQ2-epileptic encephalopathy (EE) is a neonatal epilepsy syndrome characterized by a typical clinical presentation and EEG recording, but without any brain or cortical abnormal development on MRI. Most of the patients have a severe developmental impairment. The epileptogenic mechanisms are thought to be the result of the changes of the M-current density causing a change of brain excitability. Although...

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PMID: 35584591
DOI: 10.1016/j.seizure.2022.05.008

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