The rs16906252:C>T SNP is not associated with increased overall survival or temozolomide response in a Han-Chinese glioma cohort.

doi:10.1371/journal.pone.0178842

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Article

The rs16906252:C>T SNP is not associated with increased overall survival or temozolomide response in a Han-Chinese glioma cohort.

PloS one - 1 Jan 2017

Wei Kuo-Chen, Chen Chia-Yuan, Feng Li-Ying, Huang Wei-Tzu, Chen Chia-Hua, Hsu Peng-Wei, Wang Kai, Hood Leroy E, Chen Leslie Y

Abstract excerpt

The methylation status of O-6-methylguanine-DNA methyltransferase (MGMT) is associated with the prognosis in gliomas and in other cancers. Recent studies showed that rs16906252, an SNP in the MGMT promoter, is associated with promoter methylation and is a predictor of the overall survival time (OST) and the response to temozolomide (TMZ) treatment. However, these findings haven't been systematically investigated...

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PMID: 28575062
DOI: 10.1371/journal.pone.0178842
PMCID: PMC5456392

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MGMT

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