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Article

ABCB1 gene polymorphism associated with clinical factors can predict drug-resistant tuberculosis.

Clinical science (London, England : 1979) - 1 Aug 2017

Pontual Yasmin, Pacheco Vanessa S S, Monteiro Sérgio P, Quintana Marcel S B, Costa Marli J M, Rolla Valeria C, de Castro Liane

Abstract excerpt

Polymorphism in the ABCB1 gene encoding P-glycoprotein, a transmembrane drug efflux pump, contributes to drug resistance and has been widely studied. However, their association with rifampicin and ethambutol resistance in tuberculosis (TB) patients is still unclear. Genotype/allele/haplotype frequencies in c.1236C > T (rs1128503), c.2677G > T/A (rs2032582), and c.3435C > T (rs1045642) were obtained from 218...

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Topics

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Share to Antitubercular Agents
Share to ATP Binding Cassette Transporter, Subfamily B
Share to Drug Resistance, Multiple, Bacterial
Share to Ethambutol
Share to Mycobacterium tuberculosis
Share to Nomograms
Share to Rifampin
Share to Tuberculosis, Multidrug-Resistant

Source

Identifiers

PMID: 28572401
DOI: 10.1042/CS20170277

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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