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Polymorphisms of SLCO1B1 Gene in Sundanese Ethnic Population of Tuberculosis Patients in Indonesia.

Acta medica Indonesiana - 1 Oct 2022

Santoso Prayudi, Juliastuti Henny, Nataprawira Heda Melinda, Soeroto Arto Yuwono, Alisjahbana Bachti, Ruslami Rovina, Debora Josephine, Sribudiani Yunia, Maskoen Ani Melani

Abstract excerpt

BACKGROUND: The blood level of rifampicin, one of the tuberculosis (TB) drugs, depends on the organic anion transporting polypeptide 1B1 (OATP1B1) in hepatocytes. This protein is encoded by the solute carrier organic anion 1B1 (SLCO1B1) gene. Its genetic variation has been reported to have an impact on clinical outcomes and drug efficacy. However, the polymorphism in the SLCO1B1 gene has not been examined in...

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PMID: 36624704

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