Article
Genetic variation of ABCB1 (rs1128503, rs1045642) and CYP2E1 rs3813867 with the duration of tuberculosis therapy: a pilot study among tuberculosis patients in Indonesia.
BMC research notes - 31 Jul 2021
Barliana Melisa Intan, Kusuma Arif Satria Wira, Insani Widya Norma, Alfian Sofa Dewi, Diantini Ajeng, Mutakin Mutakin, Rostinawati Tina, Herlambang Herlambang, Puspitasari Irma Melyani, Suwantika Auliya Abdurrohim, Abdulah Rizky
Abstract excerpt
OBJECTIVE: The risk of contracting tuberculosis (TB) and the efficacy of TB therapy are affected by several factors, including genetic variation among populations. In the Indonesian population, data on the genes involved in drug transport and metabolism of TB therapy are limited. The aim of this study was to identify the genetic profile of the ABCB1 gene (rs1128503 and rs1045642) and CYP2E1 gene (rs3813867) in...
Read the complete abstract on PubMed