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Article

Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis.

Cancer cell - 1 Jan 2005

Shaked Yuval, Bertolini Francesco, Man Shan, Rogers Michael S, Cervi Dave, Foutz Thomas, Rawn Kimberley, Voskas Daniel, Dumont Daniel J, Ben-David Yaacov, Lawler Jack, Henkin Jack, Huber Jim, Hicklin Daniel J, D'Amato Robert J, Kerbel Robert S

Abstract excerpt

Development of antiangiogenic therapies would be significantly facilitated by quantitative surrogate pharmacodynamic markers. Circulating peripheral blood endothelial cells (CECs) and/or their putative progenitor subset (CEPs) have been proposed but not yet fully validated for this purpose. Herein, we provide such validation by showing a striking correlation between highly genetically heterogeneous bFGF- or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15652753
DOI: 10.1016/j.ccr.2004.11.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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