Article
Gender difference in kidney electrolyte transport. I. Role of AT1a receptor in thiazide-sensitive Na+-Cl- cotransporter activity and expression in male and female mice.
American journal of physiology. Renal physiology - 1 Aug 2017
Li Jing, Hatano Ryo, Xu Shuhua, Wan Laxiang, Yang Lei, Weinstein Alan M, Palmer Lawrence, Wang Tong
Abstract excerpt
We studied gender differences in Na+-Cl- cotransporter (NCC) activity and expression in wild-type (WT) and AT1a receptor knockout (KO) mice. In renal clearance experiments, urine volume (UV), glomerular filtration rate, absolute Na+ (ENa) and K+ (EK), and fractional Na+ (FENa) and K+ excretion were measured and compared at peak changes after bolus intravenous injection of hydrochlorothiazide (HCTZ; 30 mg/kg). In...
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