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Article

Hypokalemia in a mouse model of Gitelman's syndrome.

American journal of physiology. Renal physiology - 1 Jun 2006

Morris Ryan G, Hoorn Ewout J, Knepper Mark A

Abstract excerpt

Hypokalemia is a prominent feature of Gitelman syndrome and a common side effect of thiazide use in the treatment of hypertension. It is widely recognized that genetic or pharmacological inhibition of the renal thiazide-sensitive sodium-chloride cotransporter (NCC) initiates the potentially sever...

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Identifiers

PMID: 16434571
DOI: 10.1152/ajprenal.00421.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16434571-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Hypokalemia in a mouse model of Gitelman's syndrome.PMID 16434571Read ↗

Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule.Semantic proximity Read ↗

Generation and analysis of the thiazide-sensitive Na+ -Cl- cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome.Semantic proximity Read ↗

Molecular insights from dysregulation of the thiazide-sensitive WNK/SPAK/NCC pathway in the kidney: Gordon syndrome and thiazide-induced hyponatraemia.Semantic proximity Read ↗

Mutations in the Na-Cl cotransporter reduce blood pressure in humans.Semantic proximity Read ↗

Intrafamilial phenotype variability in patients with Gitelman syndrome having the same mutations in their thiazide-sensitive sodium/chloride cotransporter.Semantic proximity Read ↗

Gitelman syndrome and glomerular proteinuria: a link between loss of sodium-chloride cotransporter and podocyte dysfunction?Semantic proximity Read ↗

Subjects heterozygous for genetic loss of function of the thiazide-sensitive cotransporter have reduced blood pressure.Semantic proximity Read ↗

Inactivation of the Na-Cl co-transporter (NCC) gene is associated with high BMD through both renal and bone mechanisms: analysis of patients with Gitelman syndrome and Ncc null mice.Semantic proximity Read ↗

Human and murine phenotypes associated with defects in cation-chloride cotransport.Semantic proximity Read ↗

Regulation of the renal NaCl cotransporter by the WNK/SPAK pathway: lessons learned from genetically altered animals.Semantic proximity Read ↗

Functional expression of mutations in the human NaCl cotransporter: evidence for impaired routing mechanisms in Gitelman's syndrome.Semantic proximity Read ↗

Potassium conservation is impaired in mice with reduced renal expression of Kir4.1.Semantic proximity Read ↗

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