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Article

New insight into the mechanism of mitochondrial cytochrome c function.

PloS one - 1 Jan 2017

Chertkova Rita V, Brazhe Nadezda A, Bryantseva Tatiana V, Nekrasov Alexey N, Dolgikh Dmitry A, Yusipovich Alexander I, Sosnovtseva Olga, Maksimov Georgy V, Rubin Andrei B, Kirpichnikov Mikhail P

Abstract excerpt

We investigate functional role of the P76GTKMIFA83 fragment of the primary structure of cytochrome c. Based on the data obtained by the analysis of informational structure (ANIS), we propose a model of functioning of cytochrome c. According to this model, conformational rearrangements of the P76GTKMIFA83 loop fragment have a significant effect on conformational mobility of the heme. It is suggested that the...

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PMID: 28562658
DOI: 10.1371/journal.pone.0178280
PMCID: PMC5451065

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