Article
Multiple Mutations in the Non-Ordered Red Ω-Loop Enhance the Membrane-Permeabilizing and Peroxidase-like Activity of Cytochrome c.
Biomolecules - 4 May 2022
Chertkova Rita V, Firsov Alexander M, Brazhe Nadezda A, Nikelshparg Evelina I, Bochkova Zhanna V, Bryantseva Tatyana V, Semenova Marina A, Baizhumanov Adil A, Kotova Elena A, Kirpichnikov Mikhail P, Maksimov Georgy V, Antonenko Yuriy N, Dolgikh Dmitry A
Abstract excerpt
A key event in the cytochrome c-dependent apoptotic pathway is the permeabilization of the outer mitochondrial membrane, resulting in the release of various apoptogenic factors, including cytochrome c, into the cytosol. It is believed that the permeabilization of the outer mitochondrial membrane can be induced by the peroxidase activity of cytochrome c in a complex with cardiolipin. Using a number of mutant...
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