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Article

The conserved active-site loop residues of ferrochelatase induce porphyrin conformational changes necessary for catalysis.

Biochemistry - 7 Mar 2006

Shi Zhen, Franco Ricardo, Haddad Raid, Shelnutt John A, Ferreira Gloria C

Abstract excerpt

Binding of porphyrin to murine ferrochelatase, the terminal enzyme of the heme biosynthetic pathway, is investigated by employing a set of variants harboring mutations in a putative porphyrin-binding loop. Using resonance Raman (RR) spectroscopy, the structural properties of the ferrochelatase-bound porphyrins are examined, especially with respect to the porphyrin deformation occurring in the environment of the...

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PMID: 16503645
DOI: 10.1021/bi051907i

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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