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Article

Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases.

Proceedings of the National Academy of Sciences of the United States of America - 23 Dec 2003

Liu Bei, Dai Jie, Zheng Hong, Stoilova Diliana, Sun Shaoli, Li Zihai

Abstract excerpt

Heat shock proteins have been implicated as endogenous activators for dendritic cells (DCs). Without tissue distress or death, these intracellular molecules are inaccessible to surface receptor(s) on DCs, possibly to avoid uncontrolled DC activation and breakdown of immunologic tolerance. We herein addressed this hypothesis in transgenic mice by enforcing cell surface expression of gp96, a ubiquitous heat shock...

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Share to Antibodies, Antinuclear
Share to Antigens, Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Neoplasm

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Share to Lymphocyte Culture Test, Mixed

Share to Myeloid Differentiation Factor 88

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Source

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Identifiers

PMID: 14668429
DOI: 10.1073/pnas.2635458100
PMCID: PMC307652

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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