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Article

Uridine monophosphate synthetase enables eukaryotic de novo NAD+ biosynthesis from quinolinic acid.

The Journal of biological chemistry - 7 Jul 2017

McReynolds Melanie R, Wang Wenqing, Holleran Lauren M, Hanna-Rose Wendy

Abstract excerpt

NAD+ biosynthesis is an attractive and promising therapeutic target for influencing health span and obesity-related phenotypes as well as tumor growth. Full and effective use of this target for therapeutic benefit requires a complete understanding of NAD+ biosynthetic pathways. Here, we report a previously unrecognized role for a conserved phosphoribosyltransferase in NAD+ biosynthesis. Because a required...

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PMID: 28559281
DOI: 10.1074/jbc.C117.795344
PMCID: PMC5500784

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