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Article

Aging-associated mitochondrial DNA mutations alter oxidative phosphorylation machinery and cause mitochondrial dysfunctions.

Biochimica et biophysica acta. Molecular basis of disease - 1 Sept 2017

Li Hongzhi, Shen Luxi, Hu Peiqing, Huang Rong, Cao Ying, Deng Janice, Yuan Weihua, Liu Danhui, Yang Jifeng, Gu Haihua, Bai Yidong

Abstract excerpt

Our previous study generated a series of cybrids containing mitochondria of synaptosomes from mice at different ages. The following functional analysis on these cybrids revealed an age-dependent decline of mitochondrial function. To understand the underlying mechanisms that contribute to the age-related mitochondrial dysfunction, we focused on three cybrids carrying mitochondria derived from synaptosomes of the...

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PMID: 28559044
DOI: 10.1016/j.bbadis.2017.05.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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