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Article

Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2017

Hashimoto Ryota, Joshi Sachindra Raj, Jiang Houli, Capdevila Jorge H, McMurtry Ivan F, Laniado Schwartzman Michal, Gupte Sachin A

Abstract excerpt

We have recently demonstrated that disruption of the murine cytochrome P-450 2c44 gene (Cyp2c44) exacerbates chronic hypoxia-induced pulmonary artery remodeling and hypertension in mice. Subsequently, we serendipitously found that Cyp2c44 gene disruption also increases hematopoietic stem cell (HSC) numbers in bone marrow and blood. Therefore, the objective of the present study was to investigate whether...

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Identifiers

PMID: 28550179
DOI: 10.1152/ajpheart.00785.2016
PMCID: PMC5582928

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