Article

Cxcr4 desensitization is an essential regulatory mechanism controlling the extra-follicular B cell response

2019-02-01

Abstract excerpt

The signaling axis formed by the chemokine CXCL12 and its receptor CXCR4 plays an important role in B cell development and activation and is finely regulated by a process termed desensitization. Mutations leading to a truncation of the C-terminus tail of CXCR4 and thus to a defective desensitization have been reported in two diseases, a rare immunodeficiency called the WHIM syndrome and a B cell plasmacytoma calle...

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Literature Corpus work: 626a2091-23f3-59e3-84b6-098371010dad
DOI: 10.1101/537761

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