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Article

Functional roles of the non-catalytic calcium-binding sites in the N-terminal domain of human peptidylarginine deiminase 4.

PloS one - 1 Jan 2013

Liu Yi-Liang, Tsai I-Chen, Chang Chia-Wei, Liao Ya-Fan, Liu Guang-Yaw, Hung Hui-Chih

Abstract excerpt

This study investigated the functional roles of the N-terminal Ca(2+) ion-binding sites, in terms of enzyme catalysis and stability, of peptidylarginine deiminase 4 (PAD4). Amino acid residues located in the N-terminal Ca(2+)-binding site of PAD4 were mutated to disrupt the binding of Ca(2+) ions. Kinetic data suggest that Asp155, Asp157 and Asp179, which directly coordinate Ca3 and Ca4, are essential for...

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Identifiers

PMID: 23382808
DOI: 10.1371/journal.pone.0051660
PMCID: PMC3559651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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