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Article

ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2017

Li Fei, Song Rui, Ao Lihua, Reece T Brett, Cleveland Joseph C, Dong Nianguo, Fullerton David A, Meng Xianzhong

Abstract excerpt

OBJECTIVE: Extracellular matrix proteinases are implicated in the pathogenesis of calcific aortic valve disease. The ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) enzyme is secreted, matrix-associated metalloendopeptidase, capable of degrading extracellular matrix proteins, particularly matrilin 2. We sought to determine the role of the ADAMTS5/matrilin 2 axis in mediating the...

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Source

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Identifiers

PMID: 28546218
DOI: 10.1161/ATVBAHA.117.309021
PMCID: PMC5516888

Genes

ADAMTS5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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