Article
Potential role of full-length and nonfull-length progranulin in affecting aortic valve calcification.
Journal of molecular and cellular cardiology - 1 Apr 2020
Huang Gaigai, An Liqin, Fan Mengtian, Zhang Menghao, Chen Bin, Zhu Mengying, Wu Jinghong, Liu Yan, Wang Yue, Huang Qin, Shi Qiong, Weng Yaguang
Abstract excerpt
Inflammation is implicated in the pathogenesis of calcific aortic valve disease (CAVD) which is a major contributor to cardiovascular mortality and lacks non-surgical treatment. The progranulin (PGRN) is an important immunomodulatory factor in a variety of inflammatory diseases, including rheumatoid arthritis, osteoarthritis, inflammatory bowel disease and pneumonia. However, its role in calcification of aortic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.