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Article

Determination of genetic relatedness from low-coverage human genome sequences using pedigree simulations.

Molecular ecology - 1 Aug 2017

Martin Michael D, Jay Flora, Castellano Sergi, Slatkin Montgomery

Abstract excerpt

We develop and evaluate methods for inferring relatedness among individuals from low-coverage DNA sequences of their genomes, with particular emphasis on sequences obtained from fossil remains. We suggest the major factors complicating the determination of relatedness among ancient individuals are sequencing depth, the number of overlapping sites, the sequencing error rate and the presence of contamination from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28543951
DOI: 10.1111/mec.14188
PMCID: PMC6485253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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