Article
PAI-1 gain-of-function genotype, factors increasing PAI-1 levels, and airway obstruction: The GALA II Cohort.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Sept 2017
Sherenian M G, Cho S H, Levin A, Min J-Y, Oh S S, Hu D, Galanter J, Sen S, Huntsman S, Eng C, Rodriguez-Santana J R, Serebrisky D, Avila P C, Kalhan R, Smith L J, Borrell L N, Seibold M A, Keoki Williams L, Burchard E G, Kumar R
Abstract excerpt
BACKGROUND: PAI-1 gain-of-function variants promote airway fibrosis and are associated with asthma and with worse lung function in subjects with asthma. OBJECTIVE: We sought to determine whether the association of a gain-of-function polymorphism in plasminogen activator inhibitor-1 (PAI-1) with airway obstruction is modified by asthma status, and whether any genotype effect persists after accounting for common...
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