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Article

Plasminogen activator inhibitor-1 and asthma: role in the pathogenesis and molecular regulation.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Aug 2009

Ma Z, Paek D, Oh C K

Abstract excerpt

Plasminogen activator inhibitor (PAI)-1 is a major inhibitor of the fibrinolytic system. PAI-1 levels are markedly increased in asthmatic airways, and mast cells (MCs), a pivotal cell type in the pathogenesis of asthma, are one of the main sources of PAI-1 production. Recent studies suggest that PAI-1 may promote the development of asthma by regulating airway remodelling, airway hyperresponsiveness (AHR), and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19438580
DOI: 10.1111/j.1365-2222.2009.03272.x

Genes

AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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