Article
Association of a PAI-1 Gene Polymorphism and Early Life Infections with Asthma Risk, Exacerbations, and Reduced Lung Function.
PloS one - 1 Jan 2016
Cho Seong H, Min Jin-Young, Kim Dong Young, Oh Sam S, Torgerson Dara R, Pino-Yanes Maria, Hu Donglei, Sen Saunak, Huntsman Scott, Eng Celeste, Farber Harold J, Rodriguez-Cintron William, Rodriguez-Santana Jose R, Serebrisky Denise, Thyne Shannon M, Borrell Luisa N, Williams L Keoki, DuPont William, Seibold Max A, Burchard Esteban G, Avila Pedro C, Kumar Rajesh
Abstract excerpt
BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) is induced in airways by virus and may mediate asthmatic airway remodeling. We sought to evaluate if genetic variants and early life lower respiratory infections jointly affect asthma risk. METHODS: We included Latino children, adolescents, and young adults aged 8-21 years (1736 subjects with physician-diagnosed asthma and 1747 healthy controls) from five U.S....
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