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Article

Germline and somatic mutations in homologous recombination genes among Chinese ovarian cancer patients detected using next-generation sequencing.

Journal of gynecologic oncology - 1 Jul 2017

Zhao Qianying, Yang Jiaxin, Li Lei, Cao Dongyan, Yu Mei, Shen Keng

Abstract excerpt

OBJECTIVE: To define genetic profiling of homologous recombination (HR) deficiency in Chinese ovarian cancer patients. METHODS: we have applied next-generation sequencing to detect deleterious mutations through all exons in 31 core HR genes. Paired whole blood and frozen tumor samples from 50 Chinese women diagnosed with epithelial ovarian carcinomas were tested to identify both germline and somatic variants....

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Source

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Identifiers

PMID: 28541631
DOI: 10.3802/jgo.2017.28.e39
PMCID: PMC5447142

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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