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Germline and somatic mutations of homologous recombination-associated genes in Japanese ovarian cancer patients

28 Nov 2019

Abstract excerpt

We explored the frequency of germline and somatic mutations in homologous recombination (HR)-associated genes in major histological types of ovarian cancer. We performed targeted sequencing to assess germline and somatic mutations of 16 HR-associated genes and 4 mismatch repair (MMR) genes among 207 ovarian cancer patients (50 high-grade serous carcinomas (HGSC), 99 clear cell carcinomas (CCC), 39 endometrioid...

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CRISPR and Genetic Engineering
DNA Repair Mechanisms
PARP inhibition in cancer therapy

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31780705
DOI: 10.1038/s41598-019-54116-y

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