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Heparan Sulfate Proteoglycan Is an Important Attachment Factor for Cell Entry of Akabane and Schmallenberg Viruses

24 May 2017

Abstract excerpt

ABSTRACT Akabane virus (AKAV) and Schmallenberg virus (SBV) are members of the genus Orthobunyavirus , which are transmitted by arthropod vectors with a broad cellular tropism in vitro as well as in vivo . Both AKAV and SBV cause arthrogryposis-hydranencephaly syndrome in ruminants. The main cellular receptor and attachment factor for entry of these orthobunyaviruses are unknown. Here, we found that AKAV and SBV...

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PMID: 28539443
DOI: 10.1128/jvi.00503-17

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