Article
Mir-132/212 is required for maturation of binocular matching of orientation preference and depth perception.
Nature communications - 23 May 2017
Mazziotti Raffaele, Baroncelli Laura, Ceglia Nicholas, Chelini Gabriele, Sala Grazia Della, Magnan Christophe, Napoli Debora, Putignano Elena, Silingardi Davide, Tola Jonida, Tognini Paola, Arthur J Simon C, Baldi Pierre, Pizzorusso Tommaso
Abstract excerpt
MicroRNAs (miRNAs) are known to mediate post-transcriptional gene regulation, but their role in postnatal brain development is still poorly explored. We show that the expression of many miRNAs is dramatically regulated during functional maturation of the mouse visual cortex with miR-132/212 family being one of the top upregulated miRNAs. Age-downregulated transcripts are significantly enriched in miR-132/miR-212...
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