Article
Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions.
European journal of human genetics : EJHG - 1 Aug 2013
Amin Najaf, Hottenga Jouke-Jan, Hansell Narelle K, Janssens A Cecile J W, de Moor Marleen H M, Madden Pamela A F, Zorkoltseva Irina V, Penninx Brenda W, Terracciano Antonio, Uda Manuela, Tanaka Toshiko, Esko Tonu, Realo Anu, Ferrucci Luigi, Luciano Michelle, Davies Gail, Metspalu Andres, Abecasis Goncalo R, Deary Ian J, Raikkonen Katri, Bierut Laura J, Costa Paul T, Saviouk Viatcheslav, Zhu Gu, Kirichenko Anatoly V, Isaacs Aaron, Aulchenko Yurii S, Willemsen Gonneke, Heath Andrew C, Pergadia Michele L, Medland Sarah E, Axenovich Tatiana I, de Geus Eco, Montgomery Grant W, Wright Margaret J, Oostra Ben A, Martin Nicholas G, Boomsma Dorret I, van Duijn Cornelia M
Abstract excerpt
Personality traits are complex phenotypes related to psychosomatic health. Individually, various gene finding methods have not achieved much success in finding genetic variants associated with personality traits. We performed a meta-analysis of four genome-wide linkage scans (N=6149 subjects) of five basic personality traits assessed with the NEO Five-Factor Inventory. We compared the significant regions from the...
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