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Article

Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy.

Nature human behaviour - 1 Sept 2023

Hindley Guy, Shadrin Alexey A, van der Meer Dennis, Parker Nadine, Cheng Weiqiu, O'Connell Kevin S, Bahrami Shahram, Lin Aihua, Karadag Naz, Holen Børge, Bjella Thomas, Deary Ian J, Davies Gail, Hill W David, Bressler Jan, Seshadri Sudha, Fan Chun Chieh, Ueland Torill, Djurovic Srdjan, Smeland Olav B, Frei Oleksandr, Dale Anders M, Andreassen Ole A

Abstract excerpt

Personality and cognitive function are heritable mental traits whose genetic foundations may be distributed across interconnected brain functions. Previous studies have typically treated these complex mental traits as distinct constructs. We applied the 'pleiotropy-informed' multivariate omnibus statistical test to genome-wide association studies of 35 measures of neuroticism and cognitive function from the UK...

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Identifiers

PMID: 37365406
DOI: 10.1038/s41562-023-01630-9
PMCID: PMC10824266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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