Association of multidrug resistance-associated protein 2 single nucleotide polymorphism rs12762549 with the basal plasma levels of phase II metabolites of isoflavonoids in healthy Japanese individuals.

doi:10.1097/FPC.0b013e3283517012

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Article

Association of multidrug resistance-associated protein 2 single nucleotide polymorphism rs12762549 with the basal plasma levels of phase II metabolites of isoflavonoids in healthy Japanese individuals.

Pharmacogenetics and genomics - 1 May 2012

Kato Koji, Kusuhara Hiroyuki, Kumagai Yuji, Ieiri Ichiro, Mori Haruyuki, Ito Sumito, Nakai Yasuhiro, Maeda Kazuya, Sugiyama Yuichi

Abstract excerpt

OBJECTIVES: Multidrug resistance-associated protein 2 (MRP2; ABCC2) is an ATP-binding cassette transporter that mediates the efflux of anionic drugs and phase II metabolites. Our aim was to elucidate the impact of a single nucleotide polymorphism, rs12762549 (G>C), on the in-vivo activity of MRP2. METHODS: Plasma specimens collected from 18 healthy volunteers were subjected to an untargeted metabolomic analysis...

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PMID: 22407408
DOI: 10.1097/FPC.0b013e3283517012

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ABCC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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