A single nucleotide polymorphism of cyclin-dependent kinase inhibitor 1B (p27Kip1) associated with human vein graft failure affects growth of human venous adventitial cells but not smooth muscle cells.

doi:10.1016/j.jvs.2016.12.113

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Article

A single nucleotide polymorphism of cyclin-dependent kinase inhibitor 1B (p27Kip1) associated with human vein graft failure affects growth of human venous adventitial cells but not smooth muscle cells.

Journal of vascular surgery - 1 Jan 2018

Kenagy Richard D, Kikuchi Shinsuke, Chen Lihua, Wijelath Errol S, Stergachis Andrew B, Stamatoyannopoulos John, Tang Gale L, Clowes Alexander W, Sobel Michael

Abstract excerpt

BACKGROUND: Cyclin-dependent kinase inhibitor 1B (p27Kip1) is a cell-cycle inhibitor whose -838C>A single nucleotide polymorphism (rs36228499; hereafter called p27 SNP) has been associated with the clinical failure of peripheral vein grafts, but the functional effects of this SNP have not been demonstrated. METHODS: Human saphenous vein adventitial cells and intimal/medial smooth muscle cells (SMCs) were derived...

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PMID: 28526559
DOI: 10.1016/j.jvs.2016.12.113
PMCID: PMC5690896

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