Article
p27kip1-838C>A single nucleotide polymorphism is associated with restenosis risk after coronary stenting and modulates p27kip1 promoter activity.
Circulation - 25 Aug 2009
van Tiel Claudia M, Bonta Peter I, Rittersma Saskia Z H, Beijk Marcel A M, Bradley Edward J, Klous Anita M, Koch Karel T, Baas Frank, Jukema J Wouter, Pons Douwe, Sampietro M Lourdes, Pannekoek Hans, de Winter Robbert J, de Vries Carlie J M
Abstract excerpt
BACKGROUND: The cyclin-dependent kinase inhibitor p27(kip1) is a key regulator of smooth muscle cell and leukocyte proliferation in vascular disease, including in-stent restenosis. We therefore hypothesized that common genetic variations or single nucleotide polymorphisms in p27(kip1) may serve as a useful tool in risk stratification for in-stent restenosis. METHODS AND RESULTS: Three single nucleotide...
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