Article
Imbalance in the synthesis of collagen type I and collagen type III in smooth muscle cells derived from human varicose veins.
Journal of vascular research - 1 Jan 2000
Sansilvestri-Morel P, Rupin A, Badier-Commander C, Kern P, Fabiani J N, Verbeuren T J, Vanhoutte P M
Abstract excerpt
Varicose veins have a thickening wall. Their smooth muscle cells are disorganized as regards proliferation and production of extracellular matrix protein. An imbalance between the synthesis of collagen type I protein (collagen I) and collagen type III protein (collagen III) could explain the lack of elasticity of varicose veins. Therefore, collagen synthesis was compared in the media and in cultured smooth muscle...
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