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Evaluation of genotype-guided acenocoumarol dosing algorithms in Russian patients.

Drug metabolism and personalized therapy - 24 May 2017

Sychev Dmitriy Alexeyevich, Rozhkov Aleksandr Vladimirovich, Ananichuk Anna Viktorovna, Kazakov Ruslan Evgenyevich

Abstract excerpt

BACKGROUND: Acenocoumarol dose is normally determined via step-by-step adjustment process based on International Normalized Ratio (INR) measurements. During this time, the risk of adverse reactions is especially high. Several genotype-based acenocoumarol dosing algorithms have been created to predict ideal doses at the start of anticoagulant therapy. METHODS: Nine dosing algorithms were selected through a...

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PMID: 28525318
DOI: 10.1515/dmpt-2016-0043

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