Article
Dosing algorithms for vitamin K antagonists across VKORC1 and CYP2C9 genotypes.
Journal of thrombosis and haemostasis : JTH - 1 Mar 2017
Baranova E V, Verhoef T I, Ragia G, le Cessie S, Asselbergs F W, de Boer A, Manolopoulos V G, Maitland-van der Zee A H
Abstract excerpt
Essentials Prospective studies of pharmacogenetic-guided (PG) coumarin dosing produced varying results. EU-PACT acenocoumarol and phenprocoumon trials compared PG and non-PG dosing algorithms. Sub-analysis of EU-PACT identified differences between trial arms across VKORC1-CYP2C9 groups. Adjustment of the PG algorithm might lead to a higher benefit of genotyping. SUMMARY: Background The multicenter, single-blind,...
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