Article
Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model.
Blood - 21 Jul 2011
Elks Philip M, van Eeden Fredericus J, Dixon Giles, Wang Xingang, Reyes-Aldasoro Constantino Carlos, Ingham Philip W, Whyte Moira K B, Walmsley Sarah R, Renshaw Stephen A
Abstract excerpt
The oxygen-sensing transcription factor hypoxia-inducible factor-1α (HIF-1α) plays a critical role in the regulation of myeloid cell function. The mechanisms of regulation are not well understood, nor are the phenotypic consequences of HIF modulation in the context of neutrophilic inflammation. Species conservation across higher metazoans enables the use of the genetically tractable and transparent zebrafish...
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