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Strategies to target energy metabolism in consensus molecular subtype 3 along with Kirsten rat sarcoma viral oncogene homolog mutations for colorectal cancer therapy.

Journal of cellular physiology - 1 May 2019

Wang Gang, Wang Jun-Jie, Yin Pei-Hao, Xu Ke, Wang Yu-Zhu, Shi Feng, Gao Jing, Fu Xing-Li

Abstract excerpt

Alterations in cellular energy metabolism play a critical role in colorectal cancer (CRC), which has been identified as the deﬁnition of consensus molecular subtypes (CMSs), and CMS3 tumors exhibit energy metabolism signatures along with Kirsten rat sarcoma viral oncogene homolog (KRAS)-activating mutations. This review summarizes the relationship between CMS3 tumors associated with mutated KRAS and energy...

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Clinical Decision-Making
Colorectal Neoplasms
Consensus Sequence
Energy Metabolism
Molecular Targeted Therapy

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Patient Selection

Precision Medicine

Proto-Oncogene Proteins p21(ras)

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PMID: 30341899
DOI: 10.1002/jcp.27388

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KRAS

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