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Article

Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes.

The Journal of biological chemistry - 21 Jul 2017

Zurawski Zack, Page Brian, Chicka Michael C, Brindley Rebecca L, Wells Christopher A, Preininger Anita M, Hyde Karren, Gilbert James A, Cruz-Rodriguez Osvaldo, Currie Kevin P M, Chapman Edwin R, Alford Simon, Hamm Heidi E

Abstract excerpt

Gi/o-coupled G protein-coupled receptors can inhibit neurotransmitter release at synapses via multiple mechanisms. In addition to Gβγ-mediated modulation of voltage-gated calcium channels (VGCC), inhibition can also be mediated through the direct interaction of Gβγ subunits with the soluble N-ethylmaleimide attachment protein receptor (SNARE) complex of the vesicle fusion apparatus. Binding studies with soluble...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28515322
DOI: 10.1074/jbc.M116.773523
PMCID: PMC5519367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes.PMID 28515322Read ↗

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