Article
Evidence of innate lymphoid cell redundancy in humans.
Nature immunology - 1 Nov 2016
Vély Frédéric, Barlogis Vincent, Vallentin Blandine, Neven Bénédicte, Piperoglou Christelle, Ebbo Mikael, Perchet Thibaut, Petit Maxime, Yessaad Nadia, Touzot Fabien, Bruneau Julie, Mahlaoui Nizar, Zucchini Nicolas, Farnarier Catherine, Michel Gérard, Moshous Despina, Blanche Stéphane, Dujardin Arnaud, Spits Hergen, Distler Jörg H W, Ramming Andreas, Picard Capucine, Golub Rachel, Fischer Alain, Vivier Eric
Abstract excerpt
Innate lymphoid cells (ILCs) have potent immunological functions in experimental conditions in mice, but their contributions to immunity in natural conditions in humans have remained unclear. We investigated the presence of ILCs in a cohort of patients with severe combined immunodeficiency (SCID). All ILC subsets were absent in patients with SCID who had mutation of the gene encoding the common γ-chain cytokine...
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