Article
Brain Tumors of Glial Origin.
Advances in experimental medicine and biology - 1 Jan 2019
Waker Christopher A, Lober Robert M
Abstract excerpt
Gliomas are a heterogeneous group of tumors with evolving classification based on genotype. Isocitrate dehydrogenase (IDH) mutation is an early event in the formation of some diffuse gliomas, and is the best understood mechanism of their epigenetic dysregulation. Glioblastoma may evolve from lower-grade lesions with IDH mutations, or arise independently from copy number changes in platelet-derived growth factor...
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