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The evolving role of cancer cell line-based screens to define the impact of cancer genomes on drug response

1 Feb 2014

Abstract excerpt

Over the last decade we have witnessed the convergence of two powerful experimental designs toward a common goal of defining the molecular subtypes that underpin the likelihood of a cancer patient responding to treatment in the clinic. The first of these 'experiments' has been the systematic sequencing of large numbers of cancer genomes through the International Cancer Genome Consortium and The Cancer Genome...

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PMID: 24607840
DOI: 10.1016/j.gde.2013.12.002

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