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Article

Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature.

Development (Cambridge, England) - 12 Nov 2019

Okuhara Shigeru, Birjandi Anahid A, Adel Al-Lami Hadeel, Sagai Tomoko, Amano Takanori, Shiroishi Toshihiko, Xavier Guilherme M, Liu Karen J, Cobourne Martyn T, Iseki Sachiko

Abstract excerpt

The tongue is a highly specialised muscular organ with a complex anatomy required for normal function. We have utilised multiple genetic approaches to investigate local temporospatial requirements for sonic hedgehog (SHH) signalling during tongue development. Mice lacking a Shh cis-enhancer, MFCS4 (ShhMFCS4/-), with reduced SHH in dorsal tongue epithelium have perturbed lingual septum tendon formation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31719045
DOI: 10.1242/dev.180075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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