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Article

The heterozygous N291S mutation in the lipoprotein lipase gene impairs whole-body insulin sensitivity and affects a distinct set of plasma metabolites in humans.

Journal of clinical lipidology - 1 Jan 2000

Berg Sofia Mikkelsen, Havelund Jesper, Hasler-Sheetal Harald, Kruse Vibeke, Pedersen Andreas James Thestrup, Hansen Aleksander Bill, Nybo Mads, Beck-Nielsen Henning, Højlund Kurt, Færgeman Nils Joakim

Abstract excerpt

BACKGROUND: Mutations in the lipoprotein lipase gene causing decreased lipoprotein lipase activity are associated with surrogate markers of insulin resistance and the metabolic syndrome in humans. OBJECTIVE: We investigated the hypothesis that a heterozygous lipoprotein lipase mutation (N291S) induces whole-body insulin resistance and alterations in the plasma metabolome. METHODS: In 6 carriers of a heterozygous...

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PMID: 28502509
DOI: 10.1016/j.jacl.2017.02.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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