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Article

Kindlin-1 protects cells from oxidative damage through activation of ERK signalling.

Free radical biology & medicine - 1 Jul 2017

Emmert Hila, Patel Hitesh, Brunton Valerie G

Abstract excerpt

Kindlin-1 is a FERM domain containing adaptor protein that is found predominantly at cell-extracellular matrix adhesions where it binds to β-integrin subunits and is required for integrin activation. Loss of function mutations in the FERMT1 gene which encodes Kindlin-1 leads to the development of Kindler Syndrome (KS) an autosomal recessive skin disorder characterized by skin blistering, photosensitivity, and...

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Source

Identifiers

PMID: 28501563
DOI: 10.1016/j.freeradbiomed.2017.05.013

Genes

FERMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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