Article
Type 2 diabetes mellitus and cardiovascular health: Evidence of causal relationships in a European ancestry population.
ESC heart failure - 1 Oct 2024
Ruan Weiqiang, Zhou Xiaoqin, Li Jing, Liu Huizhen, Wang Ting, Zhang Guiying, Lin Ke
Abstract excerpt
AIMS: Type 2 diabetes mellitus (T2DM) is associated with increased cardiovascular disease (CVD) risk, but whether T2DM directly causes adverse cardiac remodelling is uncertain. We performed a comprehensive Mendelian randomization (MR) analysis to investigate the causal relevance of T2DM to CVD outcomes and cardiac structure/function. METHODS AND RESULTS: Bidirectional two-sample MR was conducted using...
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