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Type 2 diabetes mellitus and cardiovascular health: Evidence of causal relationships in a European ancestry population.

ESC heart failure - 1 Oct 2024

Ruan Weiqiang, Zhou Xiaoqin, Li Jing, Liu Huizhen, Wang Ting, Zhang Guiying, Lin Ke

Abstract excerpt

AIMS: Type 2 diabetes mellitus (T2DM) is associated with increased cardiovascular disease (CVD) risk, but whether T2DM directly causes adverse cardiac remodelling is uncertain. We performed a comprehensive Mendelian randomization (MR) analysis to investigate the causal relevance of T2DM to CVD outcomes and cardiac structure/function. METHODS AND RESULTS: Bidirectional two-sample MR was conducted using...

Topics

Humans
Diabetes Mellitus, Type 2
Genome-Wide Association Study
Cardiovascular Diseases
Mendelian Randomization Analysis
White People
Male
Female
Genetic Predisposition to Disease
Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Magnetic Resonance Imaging, Cine

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Open in PubMed Open full text

Identifiers

PMID: 38867366
DOI: 10.1002/ehf2.14877
PMCID: PMC11424321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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