Article
Targeted disruption of the mouse Npal3 gene leads to deficits in behavior, increased IgE levels, and impaired lung function.
Cytogenetic and genome research - 1 Jan 2009
Grzmil P, Konietzko J, Boehm D, Hölter S M, Hoelter S M, Aguilar-Pimentel A, Aguilar A, Javaheri A, Kalaydjiev S, Adler T, Bolle I, Adham I, Dixkens C, Wolf S, Fuchs H, Gailus-Durner V, Gailus-Durne V, Wurst W, Ollert M, Busch D H, Busch D, Schulz H, de Angelis M Hrabe, Burfeind P
Abstract excerpt
The non-imprinted in Prader-Willi/Angelman syndrome (NIPA) proteins are highly conserved receptors or transporters. Translocation of NIPA genes were found in patients with Prader-Willi syndrome, and loss-of-function of the NIPA1 gene was identified in hereditary spastic paraplegia. The family of NIPA-like domain containing (NPAL) proteins is closely related to the NIPA proteins, but to date nothing is known about...
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