Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of a brain transcription factor, NPAS3, is associated with schizophrenia and learning disability.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jul 2005

Pickard Ben S, Malloy M P, Porteous D J, Blackwood D H R, Muir W J

Abstract excerpt

A mother and daughter diagnosed with schizophrenia and schizophrenia co-morbid with mild learning disability, respectively, possess a balanced reciprocal translocation t(9,14)(q34.2;q13). Fluorescence in situ hybridization (FISH) with YAC, BAC, and cosmid probes indicate that the chromosome 14q13...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abnormalities, Multiple
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Breakage

Share to Chromosome Disorders

Share to Chromosomes, Human, Pair 14

Share to Chromosomes, Human, Pair 9

Share to Learning Disabilities

Share to Translocation, Genetic

Source

Identifiers

PMID: 15924306
DOI: 10.1002/ajmg.b.30204

Genes

NPAS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15924306-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of a brain transcription factor, NPAS3, is associated with schizophrenia and learning disability.PMID 15924306Read ↗

The NPAS3 gene--emerging evidence for a role in psychiatric illness.Semantic proximity Read ↗

Association of NPAS3 exonic variation with schizophrenia.Semantic proximity Read ↗

Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes.Semantic proximity Read ↗

WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma.Semantic proximity Read ↗

Disruption of Sodium Bicarbonate Transporter SLC4A10 in a Patient With Complex Partial Epilepsy and Mental RetardationSemantic proximity Read ↗

NPAS3 variants in schizophrenia: a neuroimaging study.Semantic proximity Read ↗

Novel transcribed sequences neighbouring a translocation breakpoint associated with schizophrenia.Semantic proximity Read ↗

Rubinstein-Taybi syndrome: molecular findings and therapeutic approaches to improve cognitive dysfunction.Semantic proximity Read ↗

The KPNA3 gene may be a susceptibility candidate for schizophrenia.Semantic proximity Read ↗

Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia.Semantic proximity Read ↗

A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia.Semantic proximity Read ↗

Inhibition of 14-3-3 Proteins Leads to Schizophrenia-Related Behavioral Phenotypes and Synaptic Defects in Mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.