Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal History and Genetic Predictors of Transformation Into Small-Cell Carcinomas From Lung Adenocarcinomas

12 May 2017

Abstract excerpt

Purpose Histologic transformation of EGFR mutant lung adenocarcinoma (LADC) into small-cell lung cancer (SCLC) has been described as one of the major resistant mechanisms for epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, the molecular pathogenesis is still unclear. Methods We investigated 21 patients with advanced EGFR-mutant LADCs that were transformed into EGFR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Lung Cancer Research Studies
Share to Lung Cancer Treatments and Mutations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28498782
DOI: 10.1200/jco.2016.71.9096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal History and Genetic Predictors of Transformation Into Small-Cell Carcinomas From Lung AdenocarcinomasPMID 28498782Read ↗

Current knowledge of small cell lung cancer transformation from non-small cell lung cancer.Semantic proximity Read ↗

Detection of acquired TERT amplification in addition to predisposing p53 and Rb pathways alterations in EGFR-mutant lung adenocarcinomas transformed into small-cell lung cancers.Semantic proximity Read ↗

Genomic alterations and clinical outcomes in patients with lung adenocarcinoma with transformation to small cell lung cancer after treatment with EGFR tyrosine kinase inhibitors: A multicenter retrospective study.Semantic proximity Read ↗

Transformation or tumor heterogeneity: Mutations in EGFR, SOX2, TP53, and RB1 persist in the histological rapid conversion from lung adenocarcinoma to small-cell lung cancer.Semantic proximity Read ↗

Clinicopathological and molecular features of non-small cell lung cancer without TKI therapy that transforms into small-cell lung cancerSemantic proximity Read ↗

Whole exome sequencing (WES) analysis of transformed small cell lung cancer (SCLC) from lung adenocarcinoma (LUAD)Semantic proximity Read ↗

Clinical characteristics and gene mutation analysis of patients with transformed small-cell lung cancerSemantic proximity Read ↗

Origins, genetic landscape, and emerging therapies of small cell lung cancer.Semantic proximity Read ↗

Evolutionary trajectories of small cell lung cancer under therapy.Semantic proximity Read ↗

Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin.Semantic proximity Read ↗

Molecular and Genetic Advances in Small Cell Lung Cancer Landscape: From Homogeneity to Diversity.Semantic proximity Read ↗

Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.